Therapeutic control of hepatitis C virus: the role of neutralizing monoclonal antibodies

Keck, Z.Y., Machida, K., Lai, M.M.C., Ball, J.K., Patel, A.H. and Foung, S.K.H. (2008) Therapeutic control of hepatitis C virus: the role of neutralizing monoclonal antibodies. Current Topics in Microbiology and Immunology, 317, pp. 1-38. (doi:10.1007/978-3-540-72146-8_1) (PMID:17990788)

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Abstract

Liver failure associated with hepatitis C virus (HCV) accounts for a substantial portion of liver transplantation. Although current therapy helps some patients with chronic HCV infection, adverse side effects and a high relapse rate are major problems. These problems are compounded in liver transplant recipients as reinfection occurs shortly after transplantation. One approach to control reinfection is the combined use of specific antivirals together with HCV-specific antibodies. Indeed, a number of human and mouse monoclonal antibodies to conformational and linear epitopes on HCV envelope proteins are potential candidates, since they have high virus neutralization potency and are directed to epitopes conserved across diverse HCV genotypes. However, a greater understanding of the factors contributing to virus escape and the role of lipoproteins in masking virion surface domains involved in virus entry will be required to help define those protective determinants most likely to give broad protection. An approach to immune escape is potentially caused by viral infection of immune cells leading to the induction hypermutation of the immunoglobulin gene in B cells. These effects may contribute to HCV persistence and B cell lymphoproliferative diseases.

Item Type:Articles
Additional Information:ISBN: 978354072144-4
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Patel, Professor Arvind
Authors: Keck, Z.Y., Machida, K., Lai, M.M.C., Ball, J.K., Patel, A.H., and Foung, S.K.H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Current Topics in Microbiology and Immunology
Publisher:Springer
ISSN:0070-217X

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