Everett, R.D. and Zafiropoulos, A. (2004) Visualization by live-cell microscopy of disruption of ND10 during herpes simplex virus type 1 infection. Journal of Virology, 78(20), pp. 11411-11415. (doi: 10.1128/jvi.78.20.11411-11415.2004)
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Publisher's URL: http://dx.doi.org/10.1128/jvi.78.20.11411-11415.2004
Abstract
ND10 structures are disrupted during herpes simplex virus type 1 (HSV-1) infection by viral regulatory protein ICP0. The significance of this effect remains controversial, partly because of a report that high-level expression of the major ND10 promyelocytic leukemia (PML) protein precludes ND10 disruption yet does not inhibit HSV-1 infection. Here we demonstrate dramatic reorganization of ND10 during HSV-1 infection by live-cell microscopy, even in the presence of overexpressed PML.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Everett, Professor Roger |
| Authors: | Everett, R.D., and Zafiropoulos, A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Journal of Virology |
| Journal Abbr.: | J. Virol. |
| ISSN: | 0022-538X |
| ISSN (Online): | 1098-5514 |
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