Axonal pathology in traumatic brain injury

Johnson, V.E., Stewart, W. and Smith, D.H. (2013) Axonal pathology in traumatic brain injury. Experimental Neurology, 246, pp. 35-43. (doi: 10.1016/j.expneurol.2012.01.013)

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Over the past 70 years, diffuse axonal injury (DAI) has emerged as one of the most common and important pathological features of traumatic brain injury (TBI). Axons in the white matter appear to be especially vulnerable to injury due to the mechanical loading of the brain during TBI. As such, DAI has been found in all severities of TBI and may represent a key pathologic substrate of mild TBI (concussion). Pathologically, DAI encompasses a spectrum of abnormalities from primary mechanical breaking of the axonal cytoskeleton, to transport interruption, swelling and proteolysis, through secondary physiological changes. Depending on the severity and extent of injury, these changes can manifest acutely as immediate loss of consciousness or confusion and persist as coma and/or cognitive dysfunction. In addition, recent evidence suggests that TBI may induce long-term neurodegenerative processes, such as insidiously progressive axonal pathology. Indeed, axonal degeneration has been found to continue even years after injury in humans, and appears to play a role in the development of Alzheimer's disease-like pathological changes. Here we review the current understanding of DAI as a uniquely mechanical injury, its histopathological identification, and its acute and chronic pathogenesis following TBI.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Stewart, Dr William
Authors: Johnson, V.E., Stewart, W., and Smith, D.H.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Experimental Neurology
Publisher:Elsevier B.V.
ISSN (Online):1090-2430
Published Online:20 January 2012

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