Lipid metabolism and HCV infection

Targett-Adams, P., Boulant, S., Douglas, M. W. and McLauchlan, J. (2010) Lipid metabolism and HCV infection. Viruses, 2(5), pp. 1195-1217. (doi:10.3390/v2051195) (PMID:21994676) (PMCID:PMC3187597)

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Abstract

Chronic infection by hepatitis C virus (HCV) can lead to severe liver disease and is a global healthcare problem. The liver is highly metabolically active and one of its key functions is to control the balance of lipid throughout the body. A number of pathologies have been linked to the impact of HCV infection on liver metabolism. However, there is also growing evidence that hepatic metabolic processes contribute to the HCV life cycle. This review summarizes the relationship between lipid metabolism and key stages in the production of infectious HCV.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Targett-Adams, Dr Paul and McLauchlan, Professor John
Authors: Targett-Adams, P., Boulant, S., Douglas, M. W., and McLauchlan, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Viruses
Publisher:MDPI
ISSN:1999-4915
ISSN (Online):1999-4915
Published Online:11 May 2010
Copyright Holders:Copyright © 2010 The Authors
First Published:First published in Viruses 2(5):1195-1217
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
656341Virus-host interactions in hepatitis C virus infectionJohn MclauchlanMedical Research Council (MRC)MC_UU_12014/1MVLS III - CENTRE FOR VIRUS RESEARCH