Lipid droplets and hepatitis C virus infection

McLauchlan, J. (2009) Lipid droplets and hepatitis C virus infection. Biochimica et Biophysica Acta: Molecular and Cell Biology of Lipids, 1791(6), pp. 552-559. (doi:10.1016/j.bbalip.2008.12.012) (PMID:19167518)

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Abstract

Lipid droplets play an important part in the life cycle of hepatitis C virus and also are markers for steatosis, which is a common condition that arises during infection. These storage organelles are targeted by the viral core protein, which forms the capsid shell. Attachment of core to lipid droplets requires a C-terminal domain within the protein that is highly conserved between different virus isolates. In infected cells, the presence of core on lipid droplets creates loci that contain viral RNA and non-structural proteins involved in genome replication. Such locations may represent sites for initiating assembly and production of nascent virions. In addition to utilising lipid droplets as part the virus life cycle, hepatitis C virus induces their accumulation in infected hepatocytes. The mechanisms involved in this process are not understood but evidence from patient-based studies and model systems suggests the involvement of both viral and host factors.

Item Type:Articles
Additional Information:Lipid Droplets as dynamic organelles connecting influx, efflux and storage of lipids
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McLauchlan, Professor John
Authors: McLauchlan, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Biochimica et Biophysica Acta: Molecular and Cell Biology of Lipids
ISSN:1388-1981
Published Online:03 January 2009

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
656341Virus-host interactions in hepatitis C virus infectionJohn MclauchlanMedical Research Council (MRC)MC_UU_12014/1MVLS III - CENTRE FOR VIRUS RESEARCH