Herpes simplex virus IE63 acts at the posttranscriptional level to stimulate viral mRNA 3' processing

McLauchlan, J., Phelan, A., Loney, C., Sandri-Goldin, R.M. and Clements, J.B. (1992) Herpes simplex virus IE63 acts at the posttranscriptional level to stimulate viral mRNA 3' processing. Journal of Virology, 66(12), pp. 6939-6945.

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Publisher's URL: http://jvi.asm.org/content/66/12/6939.abstract

Abstract

We have shown previously that a novel herpes simplex virus-induced activity, LPF, selectively increases RNA 3'-end processing at the poly(A) site of a late virus gene (J. McLauchlan, S. Simpson, and J. B. Clements, Cell 59:1093-1105, 1989). Here, our in vivo and in vitro analyses both demonstrate that LPF is induced during early stages of virus infection. Studies of virus mutants indicate that expression of the immediate-early IE63 gene is required for induction of this activity. The selective effects on 3' processing displayed in the presence of IE63 provide direct evidence that IE63 can influence this posttranscription process. This extends previous studies which reported increases in reporter gene activity with certain poly(A) sites by IE63 (R. M. Sandri-Goldin and G. E. Mendoza, Genes Dev. 6:848-863, 1992).

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Loney, Mr Colin and McLauchlan, Professor John
Authors: McLauchlan, J., Phelan, A., Loney, C., Sandri-Goldin, R.M., and Clements, J.B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Virology
ISSN:0022-538X

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