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A 3′ co-terminus of two early herpes simplex virus type 1 mRNAs

McLauchlan, J., and Clements, J.B. (1982) A 3′ co-terminus of two early herpes simplex virus type 1 mRNAs. Nucleic Acids Research, 10 (2). pp. 501-512. ISSN 0305-1048 (doi:10.1093/nar/10.2.501)

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Publisher's URL: http://dx.doi.org/10.1093/nar/10.2.501

Abstract

A 3′ co-terminus of two early herpes simplex virus type 1 mRNAs has been identified using the nuclease-S1 mapping procedure with cloned virus DNA probes. These mRNAs (5.0 kb and 1.2 kb), located within the genome region 0.56-0.60, are unspliced and are transcribed rightwards on the prototype genome orientation. The position of their 3′ ends has been located on the virus DNA sequence and lies downstream from the polyadenylation signal 5′-AATAAA-3′. This hexanucleotide sequence also was present in the complementary DNA strand and was shown to be the polyadenylation signal for a leftwards-transcribed late mRNA. The abundance within the cytoplasm of the 5.0 kb and 1.2 kb mRNAs was investigated. Results indicated that these mRNAs were regulated in concert. It is suggested that sequences at the 3′ co-terminus may be involved in their regulation.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):McLauchlan, Dr John
Authors: McLauchlan, J., and Clements, J.B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Nucleic Acids Research
Journal Abbr.:Nucl. Acids Res.
ISSN:0305-1048
ISSN (Online):1362-4962

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