Phylogenetic relationships in the family Alloherpesviridae

Waltzek, T.B., Kelley, G.O., Alfaro, M.E., Kurobe, T., Davison, A.J. and Hedrick, R.P. (2009) Phylogenetic relationships in the family Alloherpesviridae. Diseases of Aquatic Organisms, 84(3), pp. 179-194. (doi:10.3354/dao02023) (PMID:19565695)

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Abstract

Phylogenetic relationships among herpesviruses (HVs) of mammals, birds, and reptiles have been studied extensively, whereas those among other HVs are relatively unexplored. We have reconstructed the phylogenetic relationships among 13 fish and amphibian HVs using maximum likelihood and Bayesian analyses of amino acid sequences predicted from parts of the DNA polymerase and terminase genes. The relationships among 6 of these viruses were confirmed using the partial DNA polymerase data plus the complete sequences of the terminase, helicase, and triplex protein genes; the position of these viruses among all other sequenced HVs was also investigated using the complete terminase gene. The results established the monophyly of the fish and amphibian HVs (Alloherpesviridae) separate from the HVs of mammals, birds, and reptiles (Herpesviridae) and the single recognized HV of bivalve mollusks (Malacoherpesviridae) in the order Herpesvirales. Two major clades in the family Alloherpesviridae were recognized: one consisting of viruses from cyprinid and anguillid hosts and the other of viruses from ictalurid, salmonid, acipenserid, and ranid hosts. A comparison of virus and host phylogenies suggested that closely related HVs in this family may have coevolved with their hosts, whereas significant codiversification was not apparent for the more distantly related viruses.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Davison, Professor Andrew
Authors: Waltzek, T.B., Kelley, G.O., Alfaro, M.E., Kurobe, T., Davison, A.J., and Hedrick, R.P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Diseases of Aquatic Organisms
Journal Abbr.:Dis. Aquat. Org.
Publisher:Inter Research
ISSN:0177-5103
ISSN (Online):1616-1580
Published Online:27 April 2009
Copyright Holders:Copyright © 2009 Inter Research
First Published:First published in Diseases of Aquatic Organisms 84:179-194
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
656321Genomics of human cytomegalovirusAndrew DavisonMedical Research Council (MRC)MC_UU_12014/3MVLS III - CENTRE FOR VIRUS RESEARCH