Stevenson, D., Colman, K.L., and Davison, A.J. (1994) Delineation of a sequence required for nuclear localization of the protein encoded by varicella-zoster virus gene 61. Journal of General Virology, 75 (11). pp. 3229-3233. ISSN 0022-1317 (doi:10.1099/0022-1317-75-11-3229)
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Publisher's URL: http://dx.doi.org/10.1099/0022-1317-75-11-3229
All characterized alphaherpesviruses encode a protein whose N-terminal region contains a novel zinc-binding motif, the CaHC 4 domain. Homology between the different proteins is in general limited to key residues in this domain. In order to identify a separate landmark site in the C3HC4 protein encoded by varicella-zoster virus gene 61, namely the region required for nuclear localization, we have analysed a range of mutants in transient expression and immunofluorescence experiments. A basic region (RGAKRR) at residues 387 to 392 was found to be required for nuclear localization, and residues 390 and 391 were critical.
|Glasgow Author(s):||Davison, Dr Andrew|
|Authors:||Stevenson, D., Colman, K.L., and Davison, A.J.|
|College/School:||College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation|
|Journal Name:||Journal of General Virology|
|Journal Abbr.:||J. Gen. Virol.|
|Publisher:||Society for General Microbiology|