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Delineation of a sequence required for nuclear localization of the protein encoded by varicella-zoster virus gene 61

Stevenson, D., Colman, K.L., and Davison, A.J. (1994) Delineation of a sequence required for nuclear localization of the protein encoded by varicella-zoster virus gene 61. Journal of General Virology, 75 (11). pp. 3229-3233. ISSN 0022-1317 (doi:10.1099/0022-1317-75-11-3229)

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Publisher's URL: http://dx.doi.org/10.1099/0022-1317-75-11-3229

Abstract

All characterized alphaherpesviruses encode a protein whose N-terminal region contains a novel zinc-binding motif, the CaHC 4 domain. Homology between the different proteins is in general limited to key residues in this domain. In order to identify a separate landmark site in the C3HC4 protein encoded by varicella-zoster virus gene 61, namely the region required for nuclear localization, we have analysed a range of mutants in transient expression and immunofluorescence experiments. A basic region (RGAKRR) at residues 387 to 392 was found to be required for nuclear localization, and residues 390 and 391 were critical.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Davison, Dr Andrew
Authors: Stevenson, D., Colman, K.L., and Davison, A.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of General Virology
Journal Abbr.:J. Gen. Virol.
Publisher:Society for General Microbiology
ISSN:0022-1317
ISSN (Online):1465-2099

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