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Genomic location and lack of phosphorylation of the HSV immediate-early polypeptide IE 12

Marsden, H.S., Lang, J., Davison, A.J., Hope, R.G., and Macdonald, D.M. (1982) Genomic location and lack of phosphorylation of the HSV immediate-early polypeptide IE 12. Journal of General Virology, 62 (1). pp. 17-27. ISSN 0022-1317 (doi:10.1099/0022-1317-62-1-17)

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Publisher's URL: http://dx.doi.org/10.1099/0022-1317-62-1-17

Abstract

Herpes simplex virus type 1 (HSV-1) induces an immediate-early (IE)polypeptide IE 12. An equivalent polypeptide coded by HSV-2 which migrated slightly more slowly on SDS-polyacrylamide gels was identified and designated IE 12.3. Analysis of the serotype of the IE polypeptide induced by five H~V-1/HSV-2 intertypic recombinants when correlated with their genome structures showed that IE 12/ IE 12.3 mapped in the region spanning the TRs/U s junction. Unlike four other IE polypeptides induced by HSV-1 (IEs 175, 110, 68 and 63), IE 12 was not detectably phosphorylated.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Davison, Dr Andrew
Authors: Marsden, H.S., Lang, J., Davison, A.J., Hope, R.G., and Macdonald, D.M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of General Virology
Publisher:Society for General Microbiology
ISSN:0022-1317
ISSN (Online):1465-2099

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