Characterization and manipulation of the human adenovirus 4 genome

Jacobs, S.C., Davison, A.J. , Carr, S., Bennett, A.M., Phillpotts, R. and Wilkinson, G.W.G. (2004) Characterization and manipulation of the human adenovirus 4 genome. Journal of General Virology, 85(11), pp. 3361-3366. (doi:10.1099/vir.0.80386-0)

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Publisher's URL: http://dx.doi.org/10.1099/vir.0.80386-0

Abstract

Human adenovirus 4 (HAdV-4), the only serotype of the species HAdV-E to be isolated from man, was first identified by its association with outbreaks of acute respiratory disease in military recruits. To combat such outbreaks, a live, oral HAdV-4 vaccine that is delivered via an enteric-coated capsule was developed. This vaccine has been used for nearly 40 years and has been shown to be safe and efficacious. In this study, the complete DNA sequence (35 994 bp) of the vaccine strain is described and its genetic content is analysed. Phylogenetic comparisons confirmed that the closest sequenced relative of HAdV-4 is another serotype of HAdV-E that infects chimpanzees (SAdV-25) and that the great majority of genes in HAdV-E are related most closely to HAdV-B genes. By using the sequence data, a system was constructed to facilitate production of replication-competent HAdV-4 recombinants.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Davison, Professor Andrew
Authors: Jacobs, S.C., Davison, A.J., Carr, S., Bennett, A.M., Phillpotts, R., and Wilkinson, G.W.G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of General Virology
Journal Abbr.:J. Gen. Virol.
Publisher:Society for General Microbiology
ISSN:0022-1317
ISSN (Online):1465-2099

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