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Either orientation of the L segment of the Herpes Simplex virus genome may participate in the production of viable intertypic recombinants

Davison, A.J., and Wilkie, N.M. (1983) Either orientation of the L segment of the Herpes Simplex virus genome may participate in the production of viable intertypic recombinants. Journal of General Virology, 64 (1). pp. 247-250. ISSN 0022-1317 (doi:10.1099/0022-1317-64-1-247)

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Publisher's URL: http://dx.doi.org/10.1099/0022-1317-64-1-247

Abstract

We have analysed the genome structures of 90 recombinant viruses produced by co-infection of baby hamster kidney cells with the DNA of a herpes simplex virus type 1 temperature-sensitive mutant (tsD) and specific DNA fragments of wild-type herpes simplex virus type 2 at non-permissive temperature. Crossovers were located predominantly in regions of greatest intertypic homology, and we conclude that primary recombination occurred with the L segment of the genome in either orientation.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Davison, Dr Andrew
Authors: Davison, A.J., and Wilkie, N.M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of General Virology
Journal Abbr.:J. Gen. Virol.
Publisher:Society for General Microbiology
ISSN:0022-1317
ISSN (Online):1465-2099

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