Davison, A.J., and Wilkie, N.M. (1981) Nucleotide sequences of the joint between the L and S segments of Herpes Simplex virus types 1 and 2. Journal of General Virology, 55 (2). pp. 315-331. ISSN 0022-1317 (doi:10.1099/0022-1317-55-2-315)
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Publisher's URL: http://dx.doi.org/10.1099/0022-1317-55-2-315
The a sequence of herpes simplex virus (HSV) is present as a direct repeat at the genomic termini and also in inverted orientation at thc joint between the L and S segments. DNA sequences have been determined for the joint regions of the genomes of HSV-I and HSV-2, and relative to these sequences the genomic termini are in both cases located close to a short direct repeat of 17 to 21 base pairs (bp) at the b-a and a-c junctions. The HSV-I joint region contains three separate tandem direct reiterations of short sequences, (12, 16 and 17 bp in strain 17) and we conclude that size heterogeneity in'the a and c sequences is due to variable copy numbers of these repeated units. It is likely that a considerable part of the HSV-i joint region does not code for polypeptide.
|Glasgow Author(s):||Davison, Dr Andrew|
|Authors:||Davison, A.J., and Wilkie, N.M.|
|College/School:||College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation|
|Journal Name:||Journal of General Virology|
|Publisher:||Society for General Microbiology|