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DNA sequence of the major inverted repeat in the Varicella-Zoster virus genome

Davison, A.J., and Scott, J.E. (1985) DNA sequence of the major inverted repeat in the Varicella-Zoster virus genome. Journal of General Virology, 66 (2). pp. 207-220. ISSN 0022-1317 (doi:10.1099/0022-1317-66-2-207)

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Publisher's URL: http://dx.doi.org/10.1099/0022-1317-66-2-207

Abstract

The major inverted repeat of 7319.5 base pairs is present at an internal site in the varicella-zoster virus genome and at one terminus. A DNA sequence of 7747 base pairs containing the repeat was determined and analysed. The G + C content of the repeat is not uniform, and is significantly higher than that of adjacent unique regions. The repeat contains a G + C-rich reiterated sequence, an A + T-rich sequence with the potential of forming a hairpin structure which may form part of an origin of DNA replication, and three open reading frames predicted to encode primary translation products with approximate molecular weights of 140 000, 30 000 and 20 000. The possibility is discussed that the expression of other open reading frames near the genome termini may depend upon genome conformation.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Davison, Dr Andrew and Scott, Mr James
Authors: Davison, A.J., and Scott, J.E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of General Virology
Journal Abbr.:J. Gen. Virol.
Publisher:Society for General Microbiology
ISSN:0022-1317
ISSN (Online):1465-2099

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