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A novel herpes simplex virus gene (UL49A) encodes a putative membrane protein with counterparts in other herpesviruses

Barnett, B.C., Dolan, A., Telford, E.A.R., Davison, A.J., and McGeoch, D.J. (1992) A novel herpes simplex virus gene (UL49A) encodes a putative membrane protein with counterparts in other herpesviruses. Journal of General Virology, 73 (8). pp. 2167-2171. ISSN 0022-1317 (doi:10.1099/0022-1317-73-8-2167)

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Publisher's URL: http://dx.doi.org/10.1099/0022-1317-73-8-2167

Abstract

Comparative analysis of DNA sequences located between the coding regions of genes UL49 and UL50 of herpes simplex virus types 1 and 2 (HSV-1 and -2) has revealed a small open reading frame (ORF) of 91 and 87 codons respectively with the characteristics of a genuine protein-coding region. The predicted protein products are clearly related and exhibit features of membrane-inserted proteins, with potential N-proximal signal peptides and C-proximal membrane anchor regions. Counterparts are present in the other sequenced alphaherpesviruses, namely varicella-zoster virus (a previously undescribed gene, 9A) and equine herpesvirus type 1 (gene 10), in the betaherpesvirus human cytomegalovirus (gene UL73) and in the gammaherpesvirus Epstein-Barr virus (gene BLRF1). Therefore, we consider that this ORF represents an additional HSV gene (UL49A) with counterparts in all sequenced alpha-, beta- and gammaherpesviruses.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McGeoch, Prof Duncan and Davison, Dr Andrew and Dolan, Mr Aidan
Authors: Barnett, B.C., Dolan, A., Telford, E.A.R., Davison, A.J., and McGeoch, D.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of General Virology
Journal Abbr.:J. Gen. Virol.
Publisher:Society for General Microbiology
ISSN:0022-1317
ISSN (Online):1465-2099

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