Jais, X., Olsson, K. M., Barbera, J. A., Blanco, I., Torbicki, A., Peacock, A., Vizza, C. D., Macdonald, P., Humbert, M. and Hoeper, M. M. (2012) Pregnancy outcomes in pulmonary arterial hypertension in the modern management era. European Respiratory Journal, 40(4), pp. 881-885. (doi: 10.1183/09031936.00141211)
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Abstract
Previous studies have reported mortality rates of up to 56% associated with pregnancy in pulmonary arterial hypertension (PAH) but the management of this disease has changed considerably in recent years. We compiled a multinational, prospective registry to examine the contemporary outcome of pregnancies in patients with PAH. During a 3-yr period, the 13 participating centres reported 26 pregnancies. Three (12%) females died and one (4%) developed right heart failure requiring urgent heart–lung transplantation. There were eight abortions; two spontaneous and six induced. 16 (62%) pregnancies were successful, i.e. the females delivered healthy babies without complications. These females had well controlled PAH (pulmonary vascular resistance (PVR) 500±352 dyn·s·cm−5); eight of them were long-term responders to calcium channel blockers. In contrast, the females who died or required transplantation had poorly controlled PAH (PVR 1,667±209 dyn·s·cm−5). Pregnancy remains associated with a substantial mortality rate in PAH. However, our results indicate that the outcome of pregnancy in PAH has improved, at least when PAH is well controlled, and particularly in long-term responders to calcium channel blockers. These data must be confirmed by larger series before the general recommendation to avoid pregnancy in all patients with PAH is reconsidered.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Peacock, Professor Andrew |
Authors: | Jais, X., Olsson, K. M., Barbera, J. A., Blanco, I., Torbicki, A., Peacock, A., Vizza, C. D., Macdonald, P., Humbert, M., and Hoeper, M. M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | European Respiratory Journal |
Publisher: | European Respiratory Society |
ISSN: | 0903-1936 |
ISSN (Online): | 1399-3003 |
Published Online: | 26 January 2012 |
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