Clark, R.L., Clements, C.J., Barrett, M.P. , Mackay, S.P., Rathnam, R.P., Owusu-Dapaah, G., Spencer, J. and Huggan, J.K. (2012) Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT. Bioorganic and Medicinal Chemistry, 20(20), pp. 6019-6033. (doi: 10.1016/j.bmc.2012.08.049)
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Abstract
A library of 1,4-benzodiazepines has been synthesised and evaluated for activity against Trypanosoma brucei, a causative parasite of Human African Trypanosomiasis (HAT). The most potent of these derivatives has an MIC value of 0.97 μM. Herein we report the design, synthesis and biological evaluation of the abovementioned compounds.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Barrett, Professor Michael |
Authors: | Clark, R.L., Clements, C.J., Barrett, M.P., Mackay, S.P., Rathnam, R.P., Owusu-Dapaah, G., Spencer, J., and Huggan, J.K. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Bioorganic and Medicinal Chemistry |
ISSN: | 0968-0896 |
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