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The products of Herpes Simplex virus type 1 gene UL26 which are involved in DNA packaging are strongly associated with empty but not with full capsids

Rixon, F.J., Cross, A.M., Addison, C., and Preston, V.G. (1988) The products of Herpes Simplex virus type 1 gene UL26 which are involved in DNA packaging are strongly associated with empty but not with full capsids. Journal of General Virology, 69 (11). pp. 2879-2891. ISSN 0022-1317 (doi:10.1099/0022-1317-69-11-2879)

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Publisher's URL: http://dx.doi.org/10.1099/0022-1317-69-11-2879

Abstract

We report on the properties of a family of related herpes simplex virus type 1 polypeptides (designated p40) of Mr around 40000. The intracellular localization of these polypeptides has been examined using monoclonal antibodies and their association with viral capsids within the nuclei of infected cells has been demonstrated directly by immunoelectron microscopy. Specific DNA staining and the use of mutants defective for DNA packaging has revealed, in contrast to earlier findings, that p40 is present in empty capsids. Protein p40 is not present as a major component of full capsids or of mature virions indicating that it is transiently associated with capsids and that its removal from capsids is linked with the process of DNA packaging.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Rixon, Dr Frazer and Preston, Dr Valerie
Authors: Rixon, F.J., Cross, A.M., Addison, C., and Preston, V.G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of General Virology
Journal Abbr.:J. Gen. Virol.
Publisher:Society for General Microbiology
ISSN:0022-1317
ISSN (Online):1465-2099

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