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Intranuclear distribution of Herpes Simplex virus type 2 DNA synthesis: Examination by light and electron microscopy

Rixon, F.J., Atkinson, M.A., and Hay, J. (1983) Intranuclear distribution of Herpes Simplex virus type 2 DNA synthesis: Examination by light and electron microscopy. Journal of General Virology, 64 (9). pp. 2087-2092. ISSN 0022-1317 (doi:10.1099/0022-1317-64-9-2087)

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Publisher's URL: http://dx.doi.org/10.1099/0022-1317-64-9-2087

Abstract

Uptake of [3H]thymidine by serum-starved baby hamster kidney cells infected with herpes simplex virus type 2 was investigated by light microscopic and electron microscopic autoradiography. The distribution of incorporated label altered throughout the period of viral DNA synthesis. It was restricted initially to a few well-defined sites within the nucleus which increased in size and spread as infection proceeded until the entire nucleus was involved. The label was not associated with any identifiable subnuclear structure although there was a high degree of association with the nuclear membrane at early times post-infection.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Rixon, Dr Frazer
Authors: Rixon, F.J., Atkinson, M.A., and Hay, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of General Virology
Journal Abbr.:J. Gen. Virol.
Publisher:Society for General Microbiology
ISSN:0022-1317
ISSN (Online):1465-2099

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