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Noninfectious L-particles supply functions which can facilitate infection by HSV-1

McLauchlan, J., Addison, C., Craigie, M.C., and Rixon, F.J. (1992) Noninfectious L-particles supply functions which can facilitate infection by HSV-1. Virology, 190 (2). pp. 682-688. ISSN 0042-6822 (doi:10.1016/0042-6822(92)90906-6)

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Publisher's URL: http://dx.doi.org/10.1016/0042-6822(92)90906-6

Abstract

The tegument of herpes simplex virus contains proteins important for the efficient initiation of infection. L-particles are noninfectious virion-related particles that lack the nucleocapsid but do contain tegument and envelope. Their ability to deliver functional proteins into cells was compared to that of virions by testing the biological activities of two tegument proteins which are present in both types of particle. Results indicated that L-particles are as efficient as virions in supplying these in a fully functional state. Thus, L-particles are biologically competent and have the potential to participate in the early stages of virus infection.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Addison, Mrs Clare and Rixon, Dr Frazer and McLauchlan, Dr John
Authors: McLauchlan, J., Addison, C., Craigie, M.C., and Rixon, F.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Virology
Publisher:Elsevier
ISSN:0042-6822
ISSN (Online):1096-0341

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