MacLean, C.A., Rixon, F.J. and Marsden, H.S. (1987) The products of gene US11 of Herpes Simplex Virus type 1 are DNA-binding and localize to the nucleoli of infected cells. Journal of General Virology, 68(7), pp. 1921-1937. (doi: 10.1099/0022-1317-68-7-1921)
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Publisher's URL: http://dx.doi.org/10.1099/0022-1317-68-7-1921
Abstract
We have used antisera raised against synthetic oligopeptides to characterize the protein products from herpes simplex virus type 1 gene Usll. These antisera recognized predominantly polypeptides of apparent molecular weight 21000 and 22000, but also polypeptides of apparent molecular weight 17500, 15000, 14000 and 1 1000. Tryptic peptide fingerprint analysis confirmed that these polypeptides were all closely related. The 21000 and 22 000 molecular weight polypeptides were shown to be DNA-binding proteins, and immune electron microscopy demonstrated their strong localization within nucleoli of infected cells.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Rixon, Dr Frazer |
Authors: | MacLean, C.A., Rixon, F.J., and Marsden, H.S. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Journal of General Virology |
Journal Abbr.: | J. Gen. Virol. |
Publisher: | Society for General Microbiology |
ISSN: | 0022-1317 |
ISSN (Online): | 1465-2099 |
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