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The products of gene US11 of Herpes Simplex Virus type 1 are DNA-binding and localize to the nucleoli of infected cells

MacLean, C.A., Rixon, F.J., and Marsden, H.S. (1987) The products of gene US11 of Herpes Simplex Virus type 1 are DNA-binding and localize to the nucleoli of infected cells. Journal of General Virology, 68 (7). pp. 1921-1937. ISSN 0022-1317 (doi:10.1099/0022-1317-68-7-1921)

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Publisher's URL: http://dx.doi.org/10.1099/0022-1317-68-7-1921

Abstract

We have used antisera raised against synthetic oligopeptides to characterize the protein products from herpes simplex virus type 1 gene Usll. These antisera recognized predominantly polypeptides of apparent molecular weight 21000 and 22000, but also polypeptides of apparent molecular weight 17500, 15000, 14000 and 1 1000. Tryptic peptide fingerprint analysis confirmed that these polypeptides were all closely related. The 21000 and 22 000 molecular weight polypeptides were shown to be DNA-binding proteins, and immune electron microscopy demonstrated their strong localization within nucleoli of infected cells.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Rixon, Dr Frazer
Authors: MacLean, C.A., Rixon, F.J., and Marsden, H.S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of General Virology
Journal Abbr.:J. Gen. Virol.
Publisher:Society for General Microbiology
ISSN:0022-1317
ISSN (Online):1465-2099

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