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Manipulation of herpes simplex virus type 1 by dielectrophoresis

Hughes, M.P., Morgan, H., Rixon, F.J., Burt, J.P.H., and Pethig, R. (1998) Manipulation of herpes simplex virus type 1 by dielectrophoresis. Biochimica et Biophysica Acta (BBA): General Subjects, 1425 (1). pp. 119-126. ISSN 0304-4165 (doi:10.1016/s0304-4165(98)00058-0)

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Publisher's URL: http://dx.doi.org/10.1016/s0304-4165(98)00058-0

Abstract

The frequency-dependent dielectrophoretic behaviour of an enveloped mammalian virus, herpes simplex virus type 1 is described. It is demonstrated that over the range 10 kHz–20 MHz, these viral particles, when suspended in an aqueous medium of conductivity 5 mS m−1, can be manipulated by both positive and negative dielectrophoresis using microfabricated electrode arrays. The observed transition from positive to negative dielectrophoresis at frequencies around 4.5 MHz is in qualitative agreement with a simple model of the virus as a conducting particle surrounded by an insulating membrane.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Rixon, Dr Frazer
Authors: Hughes, M.P., Morgan, H., Rixon, F.J., Burt, J.P.H., and Pethig, R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation > Centre for Virus Research
Journal Name:Biochimica et Biophysica Acta (BBA): General Subjects
Publisher:Elsevier BV
ISSN:0304-4165
ISSN (Online):1872-8006

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