Hart, T.J., Kohl, A. and Elliott, R.M. (2009) Role of the NSs protein in the zoonotic capacity of Orthobunyaviruses. Zoonoses and Public Health, 56(6-7), pp. 285-296. (doi: 10.1111/j.1863-2378.2008.01166.x)
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Publisher's URL: http://dx.doi.org/10.1111/j.1863-2378.2008.01166.x
Abstract
The family Bunyaviridae contains over 350 named isolates, classified into five genera: Orthobunyavirus, Hantavirus, Nairovirus, Phlebovirus and Tospovirus. The Orthobunyavirus genus contains some 170 isolates that are mainly transmitted by mosquitoes and are responsible for a range of disease syndromes in humans including self-limiting febrile illness, encephalitis and haemorrhagic fever. The viruses have a tripartite, negative-sense RNA genome. Analyses of viruses in four serogroups (Bunyamwera, California, Group C and Simbu) showed that the smallest (S) RNA segment encodes the nucleocapsid protein (N) and a non-structural protein called (NSs). The NSs protein of Bunyamwera virus (BUNV) has been shown to play a role in shut-off of host cell protein synthesis in mammalian cells, but no protein shut-off is observed in BUNV-infected mosquito cells (Aedes albopictus C6/36 cells). Protein shut-off in infected mammalian cells is achieved by global inhibition of RNA polymerase II-mediated transcription and enables the virus to overcome the host innate immune response. As innate defence mechanisms constitute a significant barrier to virus infection of different hosts, NSs would appear to play a key role in determining the zoonotic capacity of orthobunyaviruses.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Elliott, Professor Richard and Kohl, Professor Alain |
Authors: | Hart, T.J., Kohl, A., and Elliott, R.M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
Journal Name: | Zoonoses and Public Health |
ISSN: | 1863-1959 |
ISSN (Online): | 1863-2378 |
Published Online: | 02 September 2008 |
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