New insights into control of arbovirus replication and spread by insect RNA interference pathways

Donald, C. L. , Kohl, A. and Schnettler, E. (2012) New insights into control of arbovirus replication and spread by insect RNA interference pathways. Insects, 3(2), pp. 511-531. (doi: 10.3390/insects3020511)

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Arthropod-borne (arbo) viruses are transmitted by vectors, such as mosquitoes, to susceptible vertebrates. Recent research has shown that arbovirus replication and spread in mosquitoes is not passively tolerated but induces host responses to control these pathogens. Small RNA-mediated host responses are key players among these antiviral immune strategies. Studies into one such small RNA-mediated antiviral response, the exogenous RNA interference (RNAi) pathway, have generated a wealth of information on the functions of this mechanism and the enzymes which mediate antiviral activities. However, other small RNA-mediated host responses may also be involved in modulating antiviral activity. The aim of this review is to summarize recent research into the nature of small RNA-mediated antiviral responses in mosquitoes and to discuss future directions for this relatively new area of research.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Donald, Dr Claire and Schnettler, Dr Esther and Kohl, Professor Alain
Authors: Donald, C. L., Kohl, A., and Schnettler, E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Insects
ISSN (Online):2075-4450
Published Online:29 May 2012
Copyright Holders:Copyright © 2012 The Authors
First Published:First published in Insects 3(2):511-531
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
656551Arbovirus interactions with arthropod hostsAlain KohlMedical Research Council (MRC)MC_UU_12014/8MVLS III - CENTRE FOR VIRUS RESEARCH