Combined fiber modifications both to target αvβ6 and detarget the coxsackievirus–adenovirus receptor improve virus toxicity profilesIn vivobut fail to improve antitumoral efficacy relative to adenovirus serotype 5

Coughlan, L., Vallath, S., Gros, A., Giménez-Alejandre, M., Van Rooijen, N., Thomas, G.J., Baker, A.H., Cascalló, M., Alemany, R. and Hart, I.R. (2012) Combined fiber modifications both to target αvβ6 and detarget the coxsackievirus–adenovirus receptor improve virus toxicity profilesIn vivobut fail to improve antitumoral efficacy relative to adenovirus serotype 5. Human Gene Therapy, 23(9), pp. 960-979. (doi: 10.1089/hum.2011.218) (PMID:22708837)

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Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Baker, Professor Andrew and Coughlan, Dr Lynda
Authors: Coughlan, L., Vallath, S., Gros, A., Giménez-Alejandre, M., Van Rooijen, N., Thomas, G.J., Baker, A.H., Cascalló, M., Alemany, R., and Hart, I.R.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Human Gene Therapy
ISSN:1043-0342
ISSN (Online):1557-7422
Published Online:27 August 2012

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
486621Interrogation of the adenovirus hexon: A new paradigm for virus biology and application to therapeutic gene deliveryAndrew BakerBiotechnology and Biological Sciences Research Council (BBSRC)BB/G016844/1RI CARDIOVASCULAR & MEDICAL SCIENCES