Myelination: do astrocytes play a role?

Barnett, S.C. and Linington, C. (2013) Myelination: do astrocytes play a role? Neuroscientist, 19(5), pp. 442-450. (doi: 10.1177/1073858412465655)

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Publisher's URL: http://dx.doi.org/10.1177/1073858412465655

Abstract

Astrocytes are the most abundant cell type in the adult central nervous system (CNS), and their functional diversity in response to injury is now being appreciated. Astrocytes have long been considered the main player in the inhibition of CNS repair via the formation of the gliotic scar, but now it is accepted that astrocyte can play an important role in CNS repair and remyelination. Interest in the relationship between astrocytes and myelination focused initially on attempts to understand how the development of plaques of astroglial scar tissue in multiple sclerosis was related to the failure of these lesions to remyelinate. It is now considered that this is an end stage pathological response to injury, and that normally astrocytes play important roles in supporting the development and maintenance of CNS myelin. This review will focus on how this new understanding may be exploited to develop new strategies to enhance remyelination in multiple sclerosis and other diseases.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Barnett, Professor Susan and Linington, Professor Christopher
Authors: Barnett, S.C., and Linington, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Neuroscientist
ISSN:1073-8584
ISSN (Online):1089-4098
Published Online:06 November 2012

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