Solving the mystery of procollagen chain selectivity

Bulleid, N.J. (2012) Solving the mystery of procollagen chain selectivity. Nature Structural and Molecular Biology, 19(10), pp. 977-978. (doi:10.1038/nsmb.2397)

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Abstract

The recently solved crystal structure of the procollagen C propeptide reveals the basis for chain selectivity as well as an unexpected asymmetry to this homotrimeric molecule. In addition, mapping disease-causing mutations to the structure demonstrates clear correlation between severity of disease and mutation location.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Bulleid, Professor Neil
Authors: Bulleid, N.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Nature Structural and Molecular Biology
Publisher:Nature Publishing Group
ISSN:1545-9993
ISSN (Online):1545-9985
Published Online:04 October 2012

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