Migration of γδ T cells in steady-state conditions

Shekhar, S., Milling, S. and Yang, X. (2012) Migration of γδ T cells in steady-state conditions. Veterinary Immunology and Immunopathology, 147(1-2), pp. 1-5. (doi:10.1016/j.vetimm.2012.03.016)

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Abstract

The orchestrated migration of T lymphocytes is important for generating immunity and maintaining immunological tolerance. T lymphocytes can be divided into two populations, αβ T cells and γδ T cells, on the basis of their expression of different forms of the T cell receptor (TCR). γδ T cells represent an innate subset of T lymphocytes that play an important role in early immune response against a variety of pathogens, including bacteria and viruses. γδ T cells are abundant in the epithelial tissues. In ruminants and pigs, they constitute a major proportion of the blood lymphocyte pool, unlike in rodents and humans. Although recent studies using large animals have suggested that epithelial γδ T cells are the major source of γδ T cells in peripheral blood, and that they recirculate between epithelial tissues and blood via lymphatics, the migration pattern of these cells is largely unknown. The aim of this review is to provide an overview of the current knowledge on γδ T cell migration under steady-state conditions. A deeper understanding of γδ T cell migration may enable therapeutic modulation of innate immune responses.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Milling, Professor Simon
Authors: Shekhar, S., Milling, S., and Yang, X.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Veterinary Immunology and Immunopathology
ISSN:0165-2427

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