Human papillomavirus vaccination in Tanzanian schoolgirls: Cluster-randomized trial comparing 2 vaccine-delivery strategies

Watson-Jones, D. et al. (2012) Human papillomavirus vaccination in Tanzanian schoolgirls: Cluster-randomized trial comparing 2 vaccine-delivery strategies. Journal of Infectious Diseases, 206(5), pp. 678-686. (doi:10.1093/infdis/jis407)

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Publisher's URL: http://dx.doi.org/10.1093/infdis/jis407

Abstract

Background: We compared vaccine coverage achieved by 2 different delivery strategies for the quadrivalent human papillomavirus (HPV) vaccine in Tanzanian schoolgirls. Methods: In a cluster-randomized trial of HPV vaccination conducted in Tanzania, 134 primary schools were randomly assigned to class-based (girls enrolled in primary school grade [class] 6) or age-based (girls born in 1998; 67 schools per arm) vaccine delivery. The primary outcome was coverage by dose. Results: There were 3352 and 2180 eligible girls in schools randomized to class-based and age-based delivery, respectively. HPV vaccine coverage was 84.7% for dose 1, 81.4% for dose 2, and 76.1% for dose 3. For each dose, coverage was higher in class-based schools than in age-based schools (dose 1: 86.4% vs 82.0% [P = .30]; dose 2: 83.8% vs 77.8% [P = .05]; and dose 3: 78.7% vs 72.1% [P = .04]). Vaccine-related adverse events were rare. Reasons for not vaccinating included absenteeism (6.3%) and parent refusal (6.7%). School absenteeism rates prior to vaccination ranged from 8.1% to 23.5%. Conclusions: HPV vaccine can be delivered with high coverage in schools in sub-Saharan Africa. Compared with age-based vaccination, class-based vaccination located more eligible pupils and achieved higher coverage. HPV vaccination did not increase absenteeism rates in selected schools. Innovative strategies will be needed to reach out-of-school girls.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wight, Professor Danny and Remes, Dr Pieter
Authors: Watson-Jones, D., Baisley, K., Ponsiano, R., Lemme, F., Remes, P., Ross, D., Kapiga, S., Mayaud, P., de Sanjose, S., Wight, D., Changalucha, J., and Hayes, R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > MRC/CSO SPHSU
Journal Name:Journal of Infectious Diseases
Journal Abbr.:J Infect Dis.
Publisher:Oxford University Press
ISSN:0022-1899
ISSN (Online):1537-6613
Published Online:18 June 2012

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