Nikbakht, G., Rezaii, H., Stear, M.J., Talebi, M. and Mahmoudzadeh, H. (2012) Allelic polymorphism in the second exon of Ovar-DRB1 in fat-tailed sheep. Veterinary Journal, 192(3), pp. 547-549. (doi: 10.1016/j.tvjl.2011.08.025)
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Abstract
Ovar-DRB1 is one of the most important response genes in the major histocompatibility complex (MHC) class II region of sheep. Gene polymorphism in the second exon of Ovar-DRB1 in three different Iranian fat-tailed sheep breeds (Lori-Bakhtiari, Shaul and Zandi) was analyzed by either restriction fragment length polymorphisms (RFLP) or direct sequencing. A total of 92 Lori-Bakhtiari, 40 Shaul, and 47 Zandi sheep were examined. PCR–RFLP identified 17 genotypes in Lori-Bakhtiari sheep, 12 in Shaul sheep and 11 in Zandi sheep. Collectively, 24 different genotypes could be found for Iranian fat-tailed sheep. Using direct sequencing, seven new sequences in exon 2 of the Ovar-DRB1 gene were identified. Generalized linear modeling with a multinomial error structure showed that the sheep populations had significantly different allele frequencies.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Stear, Professor Mike |
| Authors: | Nikbakht, G., Rezaii, H., Stear, M.J., Talebi, M., and Mahmoudzadeh, H. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Veterinary Journal |
| Publisher: | Elsevier Ltd |
| ISSN: | 1090-0233 |
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