A quasi-nonlinear analysis of the anisotropic behaviour of human gallbladder wall

Li, W.G., Luo, X.Y. , Hill, N.A. , Ogden, R.W. , Smythe, A., Majeed, A.W. and Bird, N. (2012) A quasi-nonlinear analysis of the anisotropic behaviour of human gallbladder wall. Journal of Biomechanical Engineering, 134(10), p. 101009. (doi:10.1115/1.4007633)

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Publisher's URL: http://dx.doi.org/10.1115/1.4007633

Abstract

Estimation of biomechanical parameters of soft tissues from noninvasive measurements has clinical significance in patient-specific modeling and disease diagnosis. In this work, we present a quasi-nonlinear method that is used to estimate the elastic moduli of the human gallbladder wall. A forward approach based on a transversely isotropic membrane material model is used, and an inverse iteration is carried out to determine the elastic moduli in the circumferential and longitudinal directions between two successive ultrasound images of gallbladder. The results demonstrate that the human gallbladder behaves in an anisotropic manner, and constitutive models need to incorporate this. The estimated moduli are also nonlinear and patient dependent. Importantly, the peak stress predicted here differs from the earlier estimate from linear membrane theory. As the peak stress inside the gallbladder wall has been found to strongly correlate with acalculous gallbladder pain, reliable mechanical modeling for gallbladder tissue is crucial if this information is to be used in clinical diagnosis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Luo, Professor Xiaoyu and Hill, Professor Nicholas and Li, Dr Wenguang and Ogden, Professor Raymond
Authors: Li, W.G., Luo, X.Y., Hill, N.A., Ogden, R.W., Smythe, A., Majeed, A.W., and Bird, N.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:Journal of Biomechanical Engineering
Publisher:American Society of Mechanical Engineers
ISSN:0148-0731
ISSN (Online):1528-8951
Published Online:05 October 2012

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
489101Exploring the Mechanisms of Human Gallbladder PainXiaoyu LuoEngineering & Physical Sciences Research Council (EPSRC)EP/G015651/1M&S - MATHEMATICS