Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging

Leach, M.O. et al. (2012) Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging. European Radiology, 22(7), pp. 1451-1464. (doi: 10.1007/s00330-012-2446-x)

Abstract

Many therapeutic approaches to cancer affect the tumour vasculature, either indirectly or as a direct target. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has become an important means of investigating this action, both pre-clinically and in early stage clinical trials. For such trials, it is essential that the measurement process (i.e. image acquisition and analysis) can be performed effectively and with consistency among contributing centres. As the technique continues to develop in order to provide potential improvements in sensitivity and physiological relevance, there is considerable scope for between-centre variation in techniques. A workshop was convened by the Imaging Committee of the Experimental Cancer Medicine Centres (ECMC) to review the current status of DCE-MRI and to provide recommendations on how the technique can best be used for early stage trials. This review and the consequent recommendations are summarised here.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Jones, Professor Robert
• Authors: Leach, M.O., Morgan, B., Tofts, P.S., Buckley, D.L., Huang, W., Horsfield, M.A., Chenevert, T.L., Collins, D.J., Jackson, A., Lomas, D., Whitcher, B., Clarke, L., Plummer, R., Judson, I., Jones, R.J., Alonzi, R., Brunner, T., Koh, D.M., Murphy, P., Waterton, J.C., Parker, G., Graves, M.J., Scheenen, T.W.J., Redpath, T.W., Orton, M., Karczmar, G., Huisman, H., Barentsz, J., and Padhani, A.
• College/School: College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
• Journal Name: European Radiology
• ISSN: 0938-7994
• Published Online: 07 May 2012