Shields, P., Nemeth, B., Green, R. , Riehle, M. and Cumming, D.R.S. (2012) High-speed imaging of 2-D ionic diffusion using a 16x16-pixel CMOS ISFET array on the microfluidic scale. IEEE Sensors Journal, 12(9), pp. 2744-2749. (doi: 10.1109/JSEN.2012.2200249)
Full text not currently available from Enlighten.
Abstract
We present an electrochemical high-speed measurement for direct observation of the mixing of ions in solution over a sensor surface. The method is applied to the determination of time-varying mixing and diffusion rates in microfluidic systems. The system generates high-speed videos of the analytes under investigation as they mix, without the need for any preliminary staining or labeling and has a pixel-to-pixel pitch of 14 μm. We demonstrate ion displacement phenomena on the surface of a Si3N4-passivated complementary metal oxide semiconductor ion-sensitive field effect transistor array device and also monitor the pH change induced by the addition of sulfuric acid to normal saline. These chemical videos are recorded with a frame rate of up to 333 frames/s. By evaluating the time-varying change in ionic concentrations across the surface of the chip, we calculate time varying estimates of diffusivity coefficient values for the mixing analytes.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Green, Dr Richard and Nemeth, Mr Balazs and Cumming, Professor David and Riehle, Dr Mathis |
Authors: | Shields, P., Nemeth, B., Green, R., Riehle, M., and Cumming, D.R.S. |
College/School: | College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering |
Journal Name: | IEEE Sensors Journal |
ISSN: | 1530-437X |
ISSN (Online): | 1558-1748 |
Published Online: | 24 July 2012 |
University Staff: Request a correction | Enlighten Editors: Update this record