Nemeth, B., Tsuda, S., Busche, C. , Cronin, L. and Cumming, D.R.S. (2012) An ISFET sensor system for real-time detection of extracellular pH oscillations in slime mould. Electronics Letters, 48(3), pp. 144-146. (doi: 10.1049/el.2011.3951)
Full text not currently available from Enlighten.
Abstract
An ion sensitive field effect transistor (ISFET) array for the direct observation of physiochemical activity in a living biological specimen of a slime mould is demonstrated. The chip comprises a 64 × 64 pixel array of 10.2 × 10.2 mm sensors. The device was fabricated in a standard 0.35 µm foundry CMOS process. Using this device it was possible to observe periodic variations in pH consistent with the biological activity of slime mould with oscillatory amplitudes of 450 mV +/- 70 mV peak-to-peak, equating to 0.022 pH units at 20 mV/pH sensitivity, when taking data at a rate of 400 ms per pixel-sample. These oscillations arise from intracellular Ca<sup>2+</sup> variations giving rise to an extracellular pH change.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Busche, Dr Christopher and Nemeth, Mr Balazs and Cumming, Professor David and Cronin, Professor Lee |
| Authors: | Nemeth, B., Tsuda, S., Busche, C., Cronin, L., and Cumming, D.R.S. |
| College/School: | College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering College of Science and Engineering > School of Chemistry |
| Journal Name: | Electronics Letters |
| Publisher: | The Institution of Engineering & Technology |
| ISSN: | 0013-5194 |
| ISSN (Online): | 1350-911X |
| Published Online: | 09 February 2012 |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric