An ISFET sensor system for real-time detection of extracellular pH oscillations in slime mould

Nemeth, B., Tsuda, S., Busche, C., Cronin, L. and Cumming, D.R.S. (2012) An ISFET sensor system for real-time detection of extracellular pH oscillations in slime mould. Electronics Letters, 48(3), pp. 144-146. (doi:10.1049/el.2011.3951)

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Abstract

An ion sensitive field effect transistor (ISFET) array for the direct observation of physiochemical activity in a living biological specimen of a slime mould is demonstrated. The chip comprises a 64 × 64 pixel array of 10.2 × 10.2 mm sensors. The device was fabricated in a standard 0.35 µm foundry CMOS process. Using this device it was possible to observe periodic variations in pH consistent with the biological activity of slime mould with oscillatory amplitudes of 450 mV +/- 70 mV peak-to-peak, equating to 0.022 pH units at 20 mV/pH sensitivity, when taking data at a rate of 400 ms per pixel-sample. These oscillations arise from intracellular Ca<sup>2+</sup> variations giving rise to an extracellular pH change.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Busche, Dr Christoph and Nemeth, Mr Balazs and Cumming, Professor David and Cronin, Professor Leroy
Authors: Nemeth, B., Tsuda, S., Busche, C., Cronin, L., and Cumming, D.R.S.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
College of Science and Engineering > School of Chemistry
Journal Name:Electronics Letters
Publisher:The Institution of Engineering & Technology
ISSN:0013-5194
ISSN (Online):1350-911X
Published Online:09 February 2012

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
292521Scalable nanotechnology for integrated sensor arraysDavid CummingEngineering & Physical Sciences Research Council (EPSRC)GR/A10987/01ENG - ENGINEERING ELECTRONICS & NANO ENG
400041Electronics Design Centre for Heterogeneous SystemsDavid CummingEngineering & Physical Sciences Research Council (EPSRC)EP/D501288/1ENG - ENGINEERING ELECTRONICS & NANO ENG