Crawford, A., Macleod, M. , Schumacher, T., Corlett, L. and Gray, D. (2006) Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells. Journal of Immunology, 176(6), pp. 3498-3506. (doi: 10.4049/jimmunol.176.6.3498) (PMID:16517718)
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Abstract
B cells are well documented as APC; however, their role in supporting and programming the T cell response in vivo is still unclear. Studies using B cell-deficient mice have given rise to contradictory results. We have used mixed BM chimeric mice to define the contribution that B cells make as APC. When the B cell compartment is deficient in MHC class II, while other APC are largely normal, T cell clonal expansion is significantly reduced and the differentiation of T cells into cytokine-secreting effector cells is impaired (in particular, Th2 cells). The development of the memory T cell populations is also decreased. Although MHC class II-mediated presentation by B cells was crucial for an optimal T cell response, neither a B cell-specific lack of CD40 (influencing costimulation) nor lymphotoxin α (influencing lymphoid tissue architecture) had any effect on the T cell response. We conclude that in vivo B cells provide extra and essential Ag presentation capacity over and above that provided by dendritic cells, optimizing expansion and allowing the generation of memory and effector T cells.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Macleod, Dr Megan |
Authors: | Crawford, A., Macleod, M., Schumacher, T., Corlett, L., and Gray, D. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Journal of Immunology |
Journal Abbr.: | J. Immunol. |
Publisher: | The American Association of Immunologists |
ISSN: | 0022-1767 |
ISSN (Online): | 1550-6606 |
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