Curvedness study on atherosclerosis plaques and its implications to plaque stress

Gao, H. , Long, Q., Graves, M., Li, Z. and Gillard, J. (2010) Curvedness study on atherosclerosis plaques and its implications to plaque stress. In: 6th World Congress of Biomechanics (WCB 2010), Singapore, 1-6 Aug 2010, pp. 1507-1510. (doi: 10.1007/978-3-642-14515-5_384)

Abstract

Atherosclerosis plaque rupture has been considered to be a mechanical failure of the thin fibrous cap, resulted from extreme plaque stress. Plaque stress was affected by many factors from morphological features to biological abnormalities. In this study, geometrical factors (curvedness, fibrous cap thickness) were studied on assessing plaque vulnerability in comparison with stress analysis results obtained by fluid structure interaction from 20 human carotid atherosclerosis plaques. The results show that plaque surface curvedness could contribute to extreme stress level, especially in plaque shoulder region. General plaque stress distribution could be predicted by fibrous cap thickness and curvedness with multi-regression model. With more features included in the regression model, plaque stress could be easily calculated and used to assess plaque vulnerability.

• Item Type: Conference Proceedings
• Additional Information: IFMBE Proceedings, 2010, Volume 31, Part 6, 1507-1510
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Gao, Dr Hao
• Authors: Gao, H., Long, Q., Graves, M., Li, Z., and Gillard, J.
• College/School: College of Science and Engineering > School of Mathematics and Statistics > Mathematics