CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40

Macleod, M. , Kwakkenbos, M. J., Crawford, A., Brown, S., Stockinger, B., Schepers, K., Schumacher, T. and Gray, D. (2006) CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40. Journal of Experimental Medicine, 203(4), pp. 897-906. (doi: 10.1084/jem.20050711) (PMID:16549596) (PMCID:PMC2118277)

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Abstract

Secondary T cell responses are enhanced because of an expansion in numbers of antigen-specific (memory) cells. Using major histocompatibility complex class II tetramers we have tracked peptide-specific endogenous (non–T cell receptor transgenic) CD4 memory T cells in normal and in costimulation-deficient mice. CD4 memory T cells were detectable after immunization for more than 200 days, although decay was apparent. Memory cells generated in CD40 knockout mice by immunization with peptide-pulsed wild-type dendritic cells survived in the absence of CD40 and proliferated when boosted with peptide (plus adjuvant) in a CD40-independent fashion. However, differentiation of the memory cells into cytokine-producing effector cells did not occur in the absence of CD40. The data indicate that memory cells can be generated without passing through the effector cell stage.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Macleod, Dr Megan
Authors: Macleod, M., Kwakkenbos, M. J., Crawford, A., Brown, S., Stockinger, B., Schepers, K., Schumacher, T., and Gray, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Experimental Medicine
ISSN:0022-1007
ISSN (Online):1540-9538

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