CD4 memory T cells: What are they and what can they do?

MacLeod, M.K.L. , Clambey, E.T., Kappler, J.W. and Marrack, P. (2009) CD4 memory T cells: What are they and what can they do? Seminars in Immunology, 21(2), pp. 53-61. (doi: 10.1016/j.smim.2009.02.006)

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Publisher's URL: http://dx.doi.org/10.1016/j.smim.2009.02.006

Abstract

Immunological memory provides the basis for successful vaccines. It is important to understand the properties of memory cells. There is much known about the phenotype and functions of memory CD8 T cells, less about memory B cells, while CD4 memory T cells have proved difficult to study. Differences in the types of memory CD4 cells studied and the difficulties of tracking the small number of cells have led to conflicting and unclear results. Here we discuss the different systems used to study CD4 memory cells and ask whether, and in what circumstances, memory CD4 cells could provide protection against infections.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Macleod, Dr Megan
Authors: MacLeod, M.K.L., Clambey, E.T., Kappler, J.W., and Marrack, P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Seminars in Immunology
ISSN:1044-5323
ISSN (Online):1096-3618

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