Inhibitory inputs to four types of spinocerebellar tract neurons in the cat spinal cord

Shrestha, S.S., Bannatyne, B.A., Jankowska, E., Hammar, I., Nilsson, E. and Maxwell, D.J. (2013) Inhibitory inputs to four types of spinocerebellar tract neurons in the cat spinal cord. Neuroscience, 226, pp. 253-269. (doi:10.1016/j.neuroscience.2012.09.015)

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Publisher's URL: http://dx.doi.org/10.1016/j.neuroscience.2012.09.015

Abstract

Spinocerebellar tract neurons are inhibited by various sources of input via pathways activated by descending tracts as well as peripheral afferents. Inhibition may be used to modulate transmission of excitatory information forwarded to the cerebellum. However it may also provide information on the degree of inhibition of motoneurons and on the operation of inhibitory premotor neurons. Our aim was to extend previous comparisons of morphological substrates of excitation of spinocerebellar neurons to inhibitory input. Contacts formed by inhibitory axon terminals were characterised as either GABAergic, glycinergic or both GABAergic/glycinergic by using antibodies against vesicular GABA transporter (VGAT), glutamic acid decarboxylase (GAD) and gephyrin. Quantitative analysis revealed the presence of much higher proportions of inhibitory contacts when compared with excitatory contacts on spinal border (SB) neurons. However similar proportions of inhibitory and excitatory contacts were associated with ventral spinocerebellar tract (VSCT) and dorsal spinocerebellar tract neurons located in Clarke´s column (ccDSCT) and the dorsal horn (dhDSCT). In all of the cells, the majority of inhibitory terminals were glycinergic. The density of contacts was higher on somata and proximal versus distal dendrites of SB and VSCT neurons but more evenly distributed in ccDSCT and dhDSCT neurons. Variations in the density and distribution of inhibitory contacts found in this study may reflect differences in information on inhibitory processes forwarded by subtypes of spinocerebellar tract neurons to the cerebellum.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Bannatyne, Dr Anne and Maxwell, Professor David
Authors: Shrestha, S.S., Bannatyne, B.A., Jankowska, E., Hammar, I., Nilsson, E., and Maxwell, D.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Neuroscience
Publisher:Elsevier
ISSN:0306-4522
Published Online:13 December 2012

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
284171Spinal Interneurons: 5HT-NA receptors, actions, circuitsDavid MaxwellNational Institutes of Health (NIHBETH)UNSPECIFIEDRI NEUROSCIENCE & PSYCHOLOGY