Haque, T., Chaggar, T., Schafers, J., Atkinson, C., McAulay, K. and Crawford, D.H. (2010) Soluble CD30: a serum marker for Epstein-Barr virus-associated lymphoproliferative diseases. Journal of Medical Virology, 83(2), pp. 311-316. (doi: 10.1002/jmv.21953)
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Publisher's URL: http://dx.doi.org/10.1002/jmv.21953
Abstract
The soluble form of CD30 (sCD30), a member of tumor necrosis factor receptor superfamily, has been used as a marker of disease activity in various lymphomas. Epstein–Barr virus (EBV) is a potent stimulator of CD30 expression. The study aims to evaluate whether sCD30 can be used as a diagnostic marker for EBV-associated infectious mononucleosis (IM) and post-transplant lymphoproliferative disease (PTLD). Plasma from EBV seropositive healthy controls (N = 90), acute IM patients (n = 90), non-PTLD heart/lung transplant recipients (N = 30) and EBV-positive PTLD patients (N = 23) was tested for sCD30 using a commercially available ELISA kit. EBV DNA was tested by real time quantitative polymerase chain reaction assay. Significantly higher sCD30 levels were observed in acute IM patients (median 242.9 ng/ml) compared to EBV seropositive controls (median 15.7 ng/ml; P < 0.0001). These levels were highest in IM patients within 14 days of onset of illness. PTLD patients had significantly higher sCD30 levels (median 94 ng/ml) than healthy controls (P < 0.0001) and transplant patients (median 27 ng/ml; P = 0.0007). EBV DNA was detected mostly in acute IM and PTLD patients. In both cases there was a significant correlation between sCD30 and EBV DNA levels in plasma (P < 0.0001). This study demonstrates that sCD30 and EBV DNA levels can be used as potential markers for diagnosis of IM and PTLD.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McAulay, Dr Karen |
| Authors: | Haque, T., Chaggar, T., Schafers, J., Atkinson, C., McAulay, K., and Crawford, D.H. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Journal of Medical Virology |
| Journal Abbr.: | J. Med. Virol |
| ISSN: | 0146-6615 |
| ISSN (Online): | 1096-9071 |
| Published Online: | 22 December 2010 |
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