Abnormal neural oscillations and synchrony in schizophrenia

Uhlhaas, P. and Singer, W. (2010) Abnormal neural oscillations and synchrony in schizophrenia. Nature Reviews Neuroscience, 11(2), pp. 100-113. (doi: 10.1038/nrn2774) (PMID:20087360)

Abstract

Converging evidence from electrophysiological, physiological and anatomical studies suggests that abnormalities in the synchronized oscillatory activity of neurons may have a central role in the pathophysiology of schizophrenia. Neural oscillations are a fundamental mechanism for the establishment of precise temporal relationships between neuronal responses that are in turn relevant for memory, perception and consciousness. In patients with schizophrenia, the synchronization of beta- and gamma-band activity is abnormal, suggesting a crucial role for dysfunctional oscillations in the generation of the cognitive deficits and other symptoms of the disorder. Dysfunctional oscillations may arise owing to anomalies in the brain’s rhythm-generating networks of GABA (γ-aminobutyric acid) interneurons and in cortico-cortical connections.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Uhlhaas, Professor Peter
• Authors: Uhlhaas, P., and Singer, W.
• College/School: College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Journal Name: Nature Reviews Neuroscience
• Publisher: Nature Publishing Group
• ISSN: 1471-003X
• ISSN (Online): 1471-0048