Abnormal neural oscillations and synchrony in schizophrenia

Uhlhaas, P. and Singer, W. (2010) Abnormal neural oscillations and synchrony in schizophrenia. Nature Reviews Neuroscience, 11, pp. 100-113. (doi:10.1038/nrn2774)

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Abstract

Converging evidence from electrophysiological, physiological and anatomical studies suggests that abnormalities in the synchronized oscillatory activity of neurons may have a central role in the pathophysiology of schizophrenia. Neural oscillations are a fundamental mechanism for the establishment of precise temporal relationships between neuronal responses that are in turn relevant for memory, perception and consciousness. In patients with schizophrenia, the synchronization of beta- and gamma-band activity is abnormal, suggesting a crucial role for dysfunctional oscillations in the generation of the cognitive deficits and other symptoms of the disorder. Dysfunctional oscillations may arise owing to anomalies in the brain’s rhythm-generating networks of GABA (γ-aminobutyric acid) interneurons and in cortico-cortical connections.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Uhlhaas, Dr Peter
Authors: Uhlhaas, P., and Singer, W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Nature Reviews Neuroscience
Publisher:Nature Publishing Group
ISSN:1471-003X

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