Full text not currently available from Enlighten.
Converging evidence from electrophysiological, physiological and anatomical studies suggests that abnormalities in the synchronized oscillatory activity of neurons may have a central role in the pathophysiology of schizophrenia. Neural oscillations are a fundamental mechanism for the establishment of precise temporal relationships between neuronal responses that are in turn relevant for memory, perception and consciousness. In patients with schizophrenia, the synchronization of beta- and gamma-band activity is abnormal, suggesting a crucial role for dysfunctional oscillations in the generation of the cognitive deficits and other symptoms of the disorder. Dysfunctional oscillations may arise owing to anomalies in the brain’s rhythm-generating networks of GABA (γ-aminobutyric acid) interneurons and in cortico-cortical connections.
|Glasgow Author(s) Enlighten ID:||Uhlhaas, Dr Peter|
|Authors:||Uhlhaas, P., and Singer, W.|
|College/School:||College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology|
|Journal Name:||Nature Reviews Neuroscience|
|Publisher:||Nature Publishing Group|