Macleod, M. K. L. , McKee, A., Crawford, F., White, J., Kappler, J. and Marrack, P. (2008) CD4 memory T cells divide poorly in response to antigen because of their cytokine profile. Proceedings of the National Academy of Sciences of the United States of America, 105(38), pp. 14521-14526. (doi: 10.1073/pnas.0807449105) (PMID:18787120) (PMCID:PMC2533680)
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Abstract
Immunological memory is a hallmark of adaptive immunity, and understanding T cell memory will be central to the development of effective cell-mediated vaccines. The characteristics and functions of CD4 memory cells have not been well defined. Here we demonstrate that the increased size of the secondary response is solely a consequence of the increased antigen-specific precursor frequency within the memory pool. Memory cells proliferated less than primary responding cells, even within the same host. By analyzing the entry of primary and memory cells into the cell cycle, we found that the two populations proliferated similarly until day 5; after this time, fewer of the reactivated memory cells proliferated. At this time, fewer of the reactivated memory cells made IL-2 than primary responding cells, but more made IFNγ. Both these factors affected the low proliferation of the memory cells, because either exogenous IL-2 or inhibition of IFNγ increased the proliferation of the memory cells.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Macleod, Dr Megan |
Authors: | Macleod, M. K. L., McKee, A., Crawford, F., White, J., Kappler, J., and Marrack, P. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Proceedings of the National Academy of Sciences of the United States of America |
Publisher: | National Academy of Sciences |
ISSN: | 0027-8424 |
ISSN (Online): | 1091-6490 |
Copyright Holders: | Copyright © 2008 The National Academy of Sciences of the USA |
First Published: | First published in Proceedings of the National Academy of Sciences of the United States of America 105(38):14521-14526 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher. |
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