Cree, L.H., Balhorn, R. and Brewer, L.R. (2011) Single molecule studies of DNA-protamine interactions. Protein and Peptide Letters, 18(8), pp. 802-810.
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Abstract
Single molecule studies of protamine-DNA interactions have characterized the kinetics of protamine binding to DNA and the morphology of the toroidal subunits that comprise sperm chromatin. The results provided by these studies are reviewed, the advantage of using single molecule techniques is discussed, and the implications of the results to the structure, kinetics of toroid formation, and stability of the DNA-protamine complex are described. New measurements of DNA condensation forces induced by the binding of protamine to DNA are also presented. These forces induce a significant tension in constrained segments of DNA and may contribute to the reduction in volume and shaping of the maturing spermatid cell nucleus.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Brewer, Dr Laurence |
| Authors: | Cree, L.H., Balhorn, R., and Brewer, L.R. |
| College/School: | College of Science and Engineering > School of Physics and Astronomy |
| Journal Name: | Protein and Peptide Letters |
| Publisher: | Bentham Science Publishers |
| ISSN: | 0929-8665 |
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