How feedback inhibition shapes spike-timing-dependent plasticity and its implications for recent Schizophrenia models

Porr, B., McCabe, L., Di Prodi, P., Kolodziejski, C. and Woergoetter, F. (2011) How feedback inhibition shapes spike-timing-dependent plasticity and its implications for recent Schizophrenia models. Neural Networks, 24(6), pp. 560-567. (doi:10.1016/j.neunet.2011.03.004)

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Publisher's URL: http://dx.doi.org/10.1016/j.neunet.2011.03.004

Abstract

It has been shown that plasticity is not a fixed property but, in fact, changes depending on the location of the synapse on the neuron and/or changes of biophysical parameters. Here we investigate how plasticity is shaped by feedback inhibition in a cortical microcircuit. We use a differential Hebbian learning rule to model spike-timing dependent plasticity and show analytically that the feedback inhibition shortens the time window for LTD during spike-timing dependent plasticity but not for LTP. We then use a realistic GENESIS model to test two hypothesis about interneuron hypofunction and conclude that a reduction in GAD67 is the most likely candidate as the cause for hypofrontality as observed in Schizophrenia.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Di Prodi, Mr Paolo and Porr, Dr Bernd and McCabe, Miss Lynsey
Authors: Porr, B., McCabe, L., Di Prodi, P., Kolodziejski, C., and Woergoetter, F.
Subjects:R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Research Group:Computational neuroscience
Journal Name:Neural Networks
Publisher:Elsevier
ISSN:0893-6080
Copyright Holders:Copyright © 2011 Elsevier
First Published:First published in Neural Networks 2011 24(6):560-567
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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