Computational analysis of the flow of bile in human cystic duct

Al-Atabi, M., Ooi, R.C., Luo, X.Y. , Chin, S.B. and Bird, N.C. (2012) Computational analysis of the flow of bile in human cystic duct. Medical Engineering and Physics, 34(8), pp. 1177-1183. (doi:10.1016/j.medengphy.2011.12.006)

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Publisher's URL: http://dx.doi.org/10.1016/j.medengphy.2011.12.006

Abstract

Computational fluid dynamic (CFD) simulations of the three-dimensional flow structures in realistic cystic ducts have been performed to obtain quantitative readings of the flow parameters to compare with clinical measurements. Resin casts of real patients’ cystic ducts lumen that possess representative anatomical features were scanned to obtain three-dimensional flow domains that were used in the numerical analysis. The convoluting nature of the studied cystic ducts resulted in strong secondary flow that contributed towards a dimensionless pressure drop that is four times higher than those of a straight circular tube of an equivalent length and average diameter. The numerical pressure drop results across the cystic duct compared very well with those obtained from clinical observations which indicate that CFD is an appropriate tool to investigate the flow and functions of the biliary system. From the hydrodynamic point of view, the cystic duct lumen seems to serve as a passive resistor that strives to provide a constant amount of resistance to control the flow of bile out of the gallbladder. This is mainly achieved by the coupling of the secondary flow effects and bile rheology to provide flow resistance.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Luo, Professor Xiaoyu
Authors: Al-Atabi, M., Ooi, R.C., Luo, X.Y., Chin, S.B., and Bird, N.C.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:Medical Engineering and Physics
Publisher:Elsevier Science
ISSN:1350-4533
ISSN (Online):1873-4030
Published Online:01 January 2012

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
489101Exploring the Mechanisms of Human Gallbladder PainXiaoyu LuoEngineering & Physical Sciences Research Council (EPSRC)EP/G015651/1M&S - MATHEMATICS