Wang, H.M., Gao, H. , Luo, X.Y. , Berry, C. , Griffith, B.E., Ogden, R.W. and Wang, T.J. (2013) Structure-based finite strain modelling of the human left ventricle in diastole. International Journal for Numerical Methods in Biomedical Engineering, 29(1), pp. 83-103. (doi: 10.1002/cnm.2497)
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Publisher's URL: http://dx.doi.org/10.1002/cnm.2497
Abstract
Finite strain analyses of the left ventricle provide important information on heart function and have the potential to provide insights into the biomechanics of myocardial contractility in health and disease. Systolic dysfunction is the most common cause of heart failure; however, abnormalities of diastolic function also contribute to heart failure, and are associated with conditions including left ventricular hypertrophy and diabetes. The clinical significance of diastolic abnormalities is less well understood than systolic dysfunction, and specific treatments are presently lacking. To obtain qualitative and quantitative information on heart function in diastole, we develop a three-dimensional computational model of the human left ventricle that is derived from noninvasive imaging data. This anatomically realistic model has a rule-based fibre structure and a structure-based constitutive model. We investigate the sensitivity of this comprehensive model to small changes in the constitutive parameters and to changes in the fibre distribution. We make extensive comparisons between this model and similar models that employ different constitutive models, and we demonstrate qualitative and quantitative differences in stress and strain distributions for the different constitutive models. We also provide an initial validation of our model through comparisons to experimental data on stress and strain distributions in the left ventricle.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Luo, Professor Xiaoyu and Ogden, Professor Raymond and Gao, Dr Hao and Berry, Professor Colin |
| Authors: | Wang, H.M., Gao, H., Luo, X.Y., Berry, C., Griffith, B.E., Ogden, R.W., and Wang, T.J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Science and Engineering > School of Mathematics and Statistics |
| Journal Name: | International Journal for Numerical Methods in Biomedical Engineering |
| Publisher: | Wiley |
| ISSN: | 2040-7939 |
| ISSN (Online): | 2040-7947 |
| Published Online: | 27 June 2012 |
| Copyright Holders: | Copyright © 2012 John Wiley & Sons, Ltd |
| First Published: | First published in International Journal for Numerical Methods in Biomedical Engineering 29(1):83-103 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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