Purtill, F.S., Whitehall, S.K., Williams, E.S., McInerny, C.J. , Sharrocks, A.D. and Morgan, B.A. (2011) A homeodomain transcription factor regulates the DNA replication checkpoint in yeast. Cell Cycle, 10(4), pp. 664-670. (doi: 10.4161/cc.10.4.14824)
Full text not currently available from Enlighten.
Publisher's URL: http://dx.doi.org/10.4161/cc.10.4.14824
Abstract
Checkpoints monitor the successful completion of cell cycle processes, such as DNA replication, and also regulate the expression of cell cycle-dependent genes that are required for responses. In the model yeast Schizosaccharomyces pombe G<sub>1</sub>/S phase-specific gene expression is regulated by the MBF (also known as DSC1) transcription factor complex and is also activated by the mammalian ATM/ATR-related Rad3 DNA replication checkpoint. Here, we show that the Yox1 homeodomain transcription factor acts to co-ordinate the expression of MBF-regulated genes during the cell division cycle. Moreover, our data suggests that Yox1 is inactivated by the Rad3 DNA replication checkpoint via phosphorylation by the conserved Cds1 checkpoint kinase. Collectively, our data has implications for understanding the mechanisms underlying the coordination of cell cycle processes in eukaryotes.
| Item Type: | Articles (Other) |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McInerny, Dr Chris |
| Authors: | Purtill, F.S., Whitehall, S.K., Williams, E.S., McInerny, C.J., Sharrocks, A.D., and Morgan, B.A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Life Sciences College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Cell Cycle |
| ISSN: | 1538-4101 |
| ISSN (Online): | 1551-4005 |
| Published Online: | 15 February 2011 |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details