Interleukin-33 and the function of innate lymphoid cells

Mirchandani, A. S., Salmond, R. J. and Liew, F. Y. (2012) Interleukin-33 and the function of innate lymphoid cells. Trends in Immunology, 33(8), pp. 389-396. (doi: 10.1016/j.it.2012.04.005)

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Publisher's URL: http://dx.doi.org/10.1016/j.it.2012.04.005

Abstract

Interleukin (IL)-33 is a member of the IL-1 cytokine family that has been shown to play an important role in the induction and effector phases of type 2 immune responses. Both innate and adaptive immunity are regulated by IL-33, and many studies have shown disease-associated functions for this cytokine. Recently, IL-33 has been implicated in the function of novel innate lymphocyte populations that regulate both protective responses in parasitic infections and allergic airway inflammation. Here, we discuss recent data highlighting the dual roles of IL-33 in protective and deleterious immune responses.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liew, Prof Foo and Mirchandani, Dr Ananda and Salmond, Dr Robert
Authors: Mirchandani, A. S., Salmond, R. J., and Liew, F. Y.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Trends in Immunology
Publisher:Elsevier
ISSN:1471-4906
ISSN (Online):1471-4981
Published Online:18 May 2012
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
522591The role of nitric oxide-induced regulatory T cells in inflammationFoo LiewMedical Research Council (MRC)G0902003III -IMMUNOLOGY
445191The role of the 1L-33 in the innate and adaptive immune responses in asthmaGrace MurphyMedical Research Council (MRC)G0601422III -IMMUNOLOGY