Salt, I. P. and Palmer, T. M. (2012) Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation. Expert Opinion on Investigational Drugs, 21(8), pp. 1155-1167. (doi: 10.1517/13543784.2012.696609)
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Publisher's URL: http://dx.doi.org/10.1517/13543784.2012.696609
Abstract
AMP-activated protein kinase (AMPK) is the downstream component of a serine/threonine protein kinase cascade involved in the regulation of metabolism. Many studies have also revealed that AMPK activation can exert significant anti-inflammatory and immunosuppressive effects in a variety of cell types and models of inflammatory/autoimmune disease. Because metformin, an AMPK activator that is a favored first-line therapeutic option for type 2 diabetes, may confer benefits in chronic inflammatory diseases and cancers independent of its ability to normalize blood glucose, there is now considerable interest in identifying and exploiting AMPK's anti-inflammatory effects.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Palmer, Dr Timothy and Salt, Dr Ian |
Authors: | Salt, I. P., and Palmer, T. M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
Journal Name: | Expert Opinion on Investigational Drugs |
Publisher: | Informa Healthcare |
ISSN: | 1354-3784 |
ISSN (Online): | 1744-7658 |
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