Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation

Salt, I. P. and Palmer, T. M. (2012) Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation. Expert Opinion on Investigational Drugs, 21(8), pp. 1155-1167. (doi:10.1517/13543784.2012.696609)

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Publisher's URL: http://dx.doi.org/10.1517/13543784.2012.696609

Abstract

AMP-activated protein kinase (AMPK) is the downstream component of a serine/threonine protein kinase cascade involved in the regulation of metabolism. Many studies have also revealed that AMPK activation can exert significant anti-inflammatory and immunosuppressive effects in a variety of cell types and models of inflammatory/autoimmune disease. Because metformin, an AMPK activator that is a favored first-line therapeutic option for type 2 diabetes, may confer benefits in chronic inflammatory diseases and cancers independent of its ability to normalize blood glucose, there is now considerable interest in identifying and exploiting AMPK's anti-inflammatory effects.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Salt, Dr Ian and Palmer, Dr Tim
Authors: Salt, I. P., and Palmer, T. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Expert Opinion on Investigational Drugs
Publisher:Informa Healthcare
ISSN:1354-3784
ISSN (Online):1744-7658
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