The biochemistry and biology of the atypical chemokine receptors

Graham, G.J. , Locati, M., Mantovani, A., Rot, A. and Thelen, M. (2012) The biochemistry and biology of the atypical chemokine receptors. Immunology Letters, 145(1-2), pp. 30-38. (doi: 10.1016/j.imlet.2012.04.004)

Full text not currently available from Enlighten.

Publisher's URL: http://dx.doi.org/10.1016/j.imlet.2012.04.004

Abstract

A subset of chemokine receptors, initially called “silent” on the basis of their apparent failure to activate conventional signalling events, has recently attracted growing interest due to their ability to internalize, degrade, or transport ligands and thus modify gradients and create functional chemokine patterns in tissues. These receptors recognize distinct and complementary sets of ligands with high affinity, are strategically expressed in different cellular contexts, and lack structural determinants supporting Gαi activation, a key signalling event in cell migration. This is in keeping with the hypothesis that they have evolved to fulfil fundamentally different functions to the classical signalling chemokine receptors. Based on these considerations, these receptors (D6, Duffy antigen receptor for chemokines (DARC), CCX-CKR1 and CXCR7) are now collectively considered as an emerging class of ‘atypical’ chemokine receptors. In this article, we review the biochemistry and biology of this emerging chemokine receptor subfamily.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Graham, Professor Gerard
Authors: Graham, G.J., Locati, M., Mantovani, A., Rot, A., and Thelen, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Immunology Letters
Publisher:Elsevier BV
ISSN:0165-2478
ISSN (Online):1879-0542
Published Online:11 June 2012
Related URLs:

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
514422Regulation of the adaptive immune response by chemokine scavenging receptorsGerard GrahamMedical Research Council (MRC)G0901113III -IMMUNOLOGY